Volume 4, Issue 2 (11-2017)                   jpm 2017, 4(2): 47-53 | Back to browse issues page

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Barari M, Mohammadi N, Rahmani K, Afkhamzadeh A. Efficacy of immune response to a single dose of hepatitis B vaccine in healthcare workers not responding to complete vaccination course . jpm. 2017; 4 (2) :47-53
URL: http://jpm.hums.ac.ir/article-1-200-en.html
PHD, Infectious Diseases specialist, Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Abstract:   (213 Views)
Introduction: Prevention of hepatitis B (HBV) infection is mainly based on the vaccination of children at birth, as well as vaccination of the high risk groups such as health providers. The purpose of this study was to determine the efficacy of a single dose of hepatitis B vaccine in health care workers who were non–responders to three doses HBV vaccination.
Methods: This applicatory study was conducted using a quantitative approach. The statistical population were 99 medical personnel of three hospitals of Kurdistan province who had not proper immune response to previous three dose of hepatitis vaccine and were re-vaccinated with a single dose of hepatitis B vaccine, and one month after the first dose of the vaccine, their antibody levels were measured. The data collection tool was a checklist including information about age, sex and smoking as well as the results of receiving a dose of vaccine (Hepatitis B vaccine antibody titer). SPSS software, univariate inferential statistics, and multivariate logistic regression analysis were used to analyze the data.
Results: The results of this study showed that there is a significant relationship between smoking and reduction in immune response. In 55.6% of the vaccinated individuals, one month after the injection, antibody levels were more than 10 mIU/ml. in addtition, the results showed that smoking is significantly realted to the immune system response and results in a reduction in the immune response (P-Value<0.05).  There was no relationship between age and sex and immune response (P-Value>0.05).
Conclusion: Injection of an additional dose of hepatitis B vaccine in people who had received three doses previously and had no proper immune response was effective in more than half of the participants and it is cost effective.
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Type of Study: Research | Subject: Special
Received: 2017/03/11 | Accepted: 2017/05/29 | Published: 2018/01/16

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