Journal of Preventive Medicine
طب پیشگیری
J Prevent Med
Medical Sciences
http://jpm.hums.ac.ir
1
admin
2476-7182
2423-429X
8
10.52547/jpm
14
8888
13
fa
jalali
1405
8
1
gregorian
2026
11
1
13
online
1
fulltext
fa
اثر تمرینات ورزشی بر سطوح سیتوکین‌های التهابی و ضدالتهابی منتخب در زنان مبتلا به مولتیپل اسکلروزیس: مرور نظام‌مند و فراتحلیل
طب کار، آسیب شناسی ورزشی،فیزیولوژی ورزش
Occupational Medicine
مروری
Review
<b><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"><span style="letter-spacing:-.4pt">هدف:</span></span></span></span></b> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">این فراتحلیل با هدف بررسی تاثیر الگوی پاسخ سیتوکین‌های التهابی و ضدالتهابی منتخب به انواع تمرینات ورزشی در زنان مبتلا به مولتیپل اسکلروزیس </span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">(</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">MS</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">) انجام شده است.</span></span></span><br>
<b><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"><span style="letter-spacing:-.4pt">روش‌های انتخاب برای مطالعه: </span></span></span></span></b><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">این مطالعه با هدف شناسایی تحقیقات مرتبط، یک جستجوی نظام‌مند جامع در پایگاه‌های اطلاعاتی کلیدی داخلی و بین‌المللی</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">(PubMed, Web of Science, Scopus,</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""> Google Scholar,</span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> Magiran, NoorMags, IranDoc, SID) </span></span></span><span dir="RTL" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> انجام گرفت. بازه زمانی جستجو از ابتدای ایجاد پایگاه‌ها تا 28 اردیبهشت 1405 (18 می 2026) بود.</span></span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">داده‌های مطالعات منتخب با نرم‌افزار </span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">CMA2</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> تحلیل آماری شدند. اندازه اثر با محاسبه تفاوت میانگین استاندارد شده (</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">SMD</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">)</span></span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">و فاصله اطمینان ۹۵% تعیین گردید. از مدل اثرات تصادفی به دلیل ناهمگونی احتمالی مطالعات استفاده شد. ناهمگونی با شاخص </span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">I<sup>2</sup></span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> ارزیابی و سوگیری انتشار با فانل پلات و آزمون ایگر مورد بررسی قرار گرفت</span></span></span><br>
<b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">ترکیب مطالب و نتایج</span></span></span></b><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"><span style="letter-spacing:-.4pt">: </span></span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">در مجموع </span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">11</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> مطالعه (با 13 مداخله تمرین ورزشی) با </span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">323</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> شرکت‌کننده زن مبتلا به </span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">MS</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> مورد فراتحلیل قرار گرفتند. نتایج نشان داد که تمرینات ورزشی منجر به تغییرات آماری معنادار </span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">IL-6</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> (715/</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">96</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">=</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"></span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">I<sup>2</sup></span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">،<sup> </sup>979/2- تا 351/2</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">CI:</span></span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">، 818</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">/0</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">P=</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">،</span></span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">314</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">/0-</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">=</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"></span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">SMD</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">)، </span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">IL-10</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> </span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">(642/</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">90</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">=</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"></span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">I<sup>2</sup></span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">،<sup> </sup>787/0- تا 332/1</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">CI:</span></span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">، 615</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">/0</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">P=</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">،</span></span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">272</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">/0</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">=</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"></span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">SMD</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">) و </span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">TNF-a</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> (442/</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">77</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">=</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"></span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">I<sup>2</sup></span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">،<sup> </sup>589/1- تا 098/0</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">CI:</span></span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">، 083</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">/0</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">P=</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">،</span></span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">745</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">/0-</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">=</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"></span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">SMD</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">)</span></span></span> <span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">در مقایسه با گروه شاهد نمی‌شود.</span></span></span><br>
<b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">نتیجه‌گیری</span></span></span></b><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"><span style="letter-spacing:-.4pt">: </span></span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">فراتحلیل حاضر نشان داد که تمرینات ورزشی تأثیر معناداری بر سطوح </span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">IL-6</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black">، </span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">IL-10</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> و </span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">TNF-α</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> در زنان مبتلا به </span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">MS</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" yagut=""><span style="color:black"> ندارند. با توجه به ناهمگونی بالینی و مداخله‌ای مطالعات، تفسیر قطعی نتایج دشوار است؛ بنابراین، انجام مطالعات آینده با پروتکل‌های تمرینی استاندارد و بررسی دقیق‌تر ویژگی‌های بالینی بیماران ضروری است.</span></span></span>
تمرینات ورزشی, سیتوکین‌های التهابی, سیتوکین‌های ضدالتهابی, مولتیپل اسکلروزیس, زنان.
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