Volume 10, Issue 1 (Spring 2023)
J Prevent Med 2023, 10(1): 20-35 |
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Akbari H, Abedi A, Ghofrani M, Seyedahmadi M. Effect of Regular Physical Activity on BDNF and IL-17 Factors in Patients With Multiple Sclerosis: A Meta-analysis Study. J Prevent Med 2023; 10 (1) :20-35
URL: http://jpm.hums.ac.ir/article-1-670-en.html
URL: http://jpm.hums.ac.ir/article-1-670-en.html
1- Department of Sport Sciences, Faculty of Literature and Humanities, University of Zabol, Zabol, Iran.
2- Department of Sport Sciences, Faculty of Educational Sciences and Psychology, University of Sistan & Baluchestan, Zahedan, Iran.
3- Department of Sport Sciences, Faculty of Humanities, Velayat University, Iranshar, Iran.
2- Department of Sport Sciences, Faculty of Educational Sciences and Psychology, University of Sistan & Baluchestan, Zahedan, Iran.
3- Department of Sport Sciences, Faculty of Humanities, Velayat University, Iranshar, Iran.
Abstract: (630 Views)
Objective This study aims to meta-analyze the studies on the effects of regular physical activity on brain-derived neurotrophic factor (BDNF) and interleukin-17 (IL-17) in patients with multiple sclerosis (MS).
Methods In this study, a search was conducted for the related articles in Scopus, ScienceDirect, PubMed, and Web of Science, SID, MagIran, and IranDoc databases. Articles published until April 2021 were searched using the keywords multiple sclerosis, MS, exercise, physical activity, inflammatory and anti-inflammatory factors, and cytokines. For accuracy in selecting and evaluating the methodological quality of the studies, the physiotherapy evidence database (PEDro) scale was used. Comprehensive meta-analysis software was used for meta-analysis.
Results Of 408 found articles, 9 were finally selected based on the inclusion and exclusion criteria (six studies for BDNF and three studies for IL-17) for the meta-analysis. The meta-analysis results showed that regular physical activity did not increase the difference between the control and experimental groups in the levels of BDNF and IL-17. These exercises could not cause significant changes in people with MS.
Conclusion Although regular physical activity alone cannot affect cytokine levels in MS patients, it can be used as a complementary treatment along drug therapy in these patients, because it not only does not increase the inflammation or severity of the disease, but also can help these patients reduce the risk of secondary disorders.
Methods In this study, a search was conducted for the related articles in Scopus, ScienceDirect, PubMed, and Web of Science, SID, MagIran, and IranDoc databases. Articles published until April 2021 were searched using the keywords multiple sclerosis, MS, exercise, physical activity, inflammatory and anti-inflammatory factors, and cytokines. For accuracy in selecting and evaluating the methodological quality of the studies, the physiotherapy evidence database (PEDro) scale was used. Comprehensive meta-analysis software was used for meta-analysis.
Results Of 408 found articles, 9 were finally selected based on the inclusion and exclusion criteria (six studies for BDNF and three studies for IL-17) for the meta-analysis. The meta-analysis results showed that regular physical activity did not increase the difference between the control and experimental groups in the levels of BDNF and IL-17. These exercises could not cause significant changes in people with MS.
Conclusion Although regular physical activity alone cannot affect cytokine levels in MS patients, it can be used as a complementary treatment along drug therapy in these patients, because it not only does not increase the inflammation or severity of the disease, but also can help these patients reduce the risk of secondary disorders.
Keywords: Physical activity, Cytokines, Interleukin-17, Brain-derived neurotrophic factor, Multiple sclerosis
Type of Study: Review |
Subject:
General
Received: 2022/10/24 | Accepted: 2022/11/23 | Published: 2023/07/1
Received: 2022/10/24 | Accepted: 2022/11/23 | Published: 2023/07/1
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