----------------------------- -----------------------------
Volume 10, Issue 1 (Spring 2023)                   J Prevent Med 2023, 10(1): 20-35 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Akbari H, Abedi A, Ghofrani M, Seyedahmadi M. Effect of Regular Physical Activity on BDNF and IL-17 Factors in Patients With Multiple Sclerosis: A Meta-analysis Study. J Prevent Med 2023; 10 (1) :20-35
URL: http://jpm.hums.ac.ir/article-1-670-en.html
1- Department of Sport Sciences, Faculty of Literature and Humanities, University of Zabol, Zabol, Iran.
2- Department of Sport Sciences, Faculty of Educational Sciences and Psychology, University of Sistan & Baluchestan, Zahedan, Iran.
3- Department of Sport Sciences, Faculty of Humanities, Velayat University, Iranshar, Iran.
Abstract:   (738 Views)
Objective This study aims to meta-analyze the studies on the effects of regular physical activity on brain-derived neurotrophic factor (BDNF) and interleukin-17 (IL-17) in patients with multiple sclerosis (MS).
Methods In this study, a search was conducted for the related articles in Scopus, ScienceDirect, PubMed, and Web of Science, SID, MagIran, and IranDoc databases. Articles published until April 2021 were searched using the keywords multiple sclerosis, MS, exercise, physical activity, inflammatory and anti-inflammatory factors, and cytokines. For accuracy in selecting and evaluating the methodological quality of the studies, the physiotherapy evidence database (PEDro) scale was used. Comprehensive meta-analysis software was used for meta-analysis.
Results Of 408 found articles, 9 were finally selected based on the inclusion and exclusion criteria (six studies for BDNF and three studies for IL-17) for the meta-analysis. The meta-analysis results showed that regular physical activity did not increase the difference between the control and experimental groups in the levels of BDNF and IL-17. These exercises could not cause significant changes in people with MS.
Conclusion Although regular physical activity alone cannot affect cytokine levels in MS patients, it can be used as a complementary treatment along drug therapy in these patients, because it not only does not increase the inflammation or severity of the disease, but also can help these patients reduce the risk of secondary disorders.
Full-Text [PDF 6966 kb]   (333 Downloads) |   |   Full-Text (HTML)  (439 Views)  
Type of Study: Review | Subject: General
Received: 2022/10/24 | Accepted: 2022/11/23 | Published: 2023/07/1

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb